Is Apoquel a Janus kinase inhibitor?

Is Apoquel a Janus kinase inhibitor? Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.

What do Janus kinase inhibitors do? If you have rheumatoid arthritis (RA), your doctor may suggest Janus kinase (JAK) inhibitors to help ease your joint pain and swelling. These drugs tamp down your overactive immune system — the body’s defense against germs — to help prevent damage to your joints.

What can I give my dog instead of Apoquel? Alternatives to Apoquel include Cytopoint® injections, Atopica® pills, Temaril-P® pills, prednisone and other corticosteroids. Immunotherapy injections, allergen avoidance and frequent bathing are effective non-drug alternatives. An upgraded diet, fish oil and lifestyle modification to decrease stress can also help.

What are the side effects of Apoquel for dogs? Most commonly gastrointestinal effects (vomiting, diarrhea, anorexia), polydipsia (increased thirst) or lethargy have been noted but other potentially serious adverse effects, including susceptibility to infections (e.g., pneumonia, demodicosis), neoplasia, and skin disorders are possible.

Is Apoquel a Janus kinase inhibitor? – Additional Questions

Why do I have to wash my hands after touching Apoquel?

Humans should make sure to wash their hands thoroughly after handling Apoquel tablets. Apoquel is not a steroid, and so the list of possible side effects is much shorter compared to steroid drugs like prednisone.

Can Apoquel cause kidney failure in dogs?

There are no known effects of Apoquel® on organs such as the kidneys and liver. Some dogs have been treated with Apoquel for more than five years without any problem, and we do not expect there will be long-term problems. Dogs taking Apoquel® may have a slightly higher risk of developing bladder infections.

How long should a dog take Apoquel?

If your dog is scratching, licking, or chewing like crazy, you want to provide fast, effective relief. Apoquel starts relieving allergic dog itch within 4 hours — and controls it within 24 hours. Apoquel is given twice daily, for up to 14 days, and then once daily for maintenance therapy.

Is Apoquel same as Benadryl?

The main difference between Apoquel and Benadryl, among other allergy medications for dogs, is that it is distinctly an Immunomodulator rather than an antihistamine. What’s more, it is essentially a selective JAK (Janus kinase) inhibitor.

Can dogs be on Apoquel long term?

Apoquel can be used long-term at maintenance doses or seasonally as needed. Unlike steroids, it can be stopped without tapering. Some dogs will respond well to the initial higher doses, but experience itching again when the dose is reduced to maintenance levels.

Can Apoquel be stopped abruptly?

Unlike steroids, (that patients must be weaned off slowly over a number of weeks), Apoquel can be stopped suddenly then restarted again at a lower dose.

Can Apoquel cause death in dogs?

Here are some of the serious side effects noted: One dog was euthanized after 450 days of Apoquel. The dog had developed abdominal ascites and pleural effusion of unknown etiology.

Can CBD replace Apoquel?

CBD to Treat Side Effects of Apoquel

Not only does a full-spectrum hemp extract offer supportive and effective relief from allergies and their symptoms, but many of its healing properties also produce the opposite effect of Apoquel’s side effects.

Does Apoquel make dogs sleepy?

One of the less common apoquel side effects in dogs is lethargy. So, there is a chance that apoquel will make your dog feel sleepy and cause lower activity levels.

Which is better Apoquel or Benadryl?

To recap: Apoquel may work better for long-term solutions to pruritus, but Benadryl will be fine in a pinch until you can get something better.

Does Apoquel help with itchy ears?

There are also steroids, antihistamines, and newer anti-itch allergy medications like Apoquel and Cytopoint that can help reduce ear and skin issues in allergic dogs. Regular ear cleaning and even a cleaning product to reduce wax can help reduce ear infections in allergic dogs.

Can Apoquel make my dog aggressive?

New and innovative drugs can cause undesired behaviour changes too; oclacitinib (Apoquel; Zoetis), used to control pruritus in dogs with allergic dermatitis, has been found to be associated with increased aggression (Cosgrove and others 2013).

Does Apoquel cause mast cell tumors?

Two dogs each developed a Grade II mast cell tumor after 52 and 91 days of APOQUEL administration, respectively. One dog developed low grade B-cell lymphoma after 392 days of APOQUEL administration.

Is Apoquel addictive to dogs?

As disturbing as the side effects of Apoquel seem to be, the real threat of this drug in my mind is how addictive it is to your dog’s system. Apoquel is not a drug meant for acute conditions, but instead for skin issues that have typically plagued a dog for a long time.

Does Apoquel make dogs urinate more?

What are Apoquel Side Effects? Apoquel is a drug designed to relieve itchy skin in dogs. It has gained in popularity over the last few years because it has less systemic side effects than corticosteroids – namely weight gain, polyurea (increased urination), and organ damage.

Why do you need to wear gloves with Apoquel?

Prolonged skin contact may cause temporary irritation. Causes serious eye damage.

Does Apoquel make dogs put on weight?

Similarly to the side effect of weight gain seen in humans on JAK inhibitors, I have seen weight gain in dogs on Apoquel, not to the degree seen with steroids. I have not had owners report an increased appetite. Perhaps they are getting less exercise from not scratching as much.